Harnessing FOXP3+ regulatory T cells for transplantation tolerance.

نویسندگان

  • Herman Waldmann
  • Robert Hilbrands
  • Duncan Howie
  • Stephen Cobbold
چکیده

Early demonstrations that mice could be tolerized to transplanted tissues with short courses of immunosuppressive therapy and that with regard to tolerance to self, CD4+FOXP3+ regulatory T cells (Tregs) appeared to play a critical role, have catalyzed strategies to harness FOXP3-dependent processes to control rejection in human transplantation. This review seeks to examine the scientific underpinning for this new approach to finesse immunosuppression.

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عنوان ژورنال:
  • The Journal of clinical investigation

دوره 124 4  شماره 

صفحات  -

تاریخ انتشار 2014